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Dr. Malcolm D’Souza

Professor of Chemistry and Dean of Interdisciplinary/Collaborative Sponsored Research

Why I Teach

To inspire undergraduates to be resilient, collaborative and successful.

Professional Activities

In addition to my research in physical organic chemistry, I have projects, presentations, and publications in the areas of chemometrics, STEM education, obesity studies, and in the design of commercial databases that assist in the development of new pharmaceutical and agricultural products. 115 Wesley College undergraduates from my laboratory have earned national and regional recognitions, and 72 undergraduates are co-authors on 65 peer-reviewed publications.

I am the Principal Investigator on the Wesley College NIH-NIGMS (IDeA) INBRE, NSF-EPSCoR, NSF ARRA, Cannon Scholar (NSF S-STEM), and DEDO programs. In 2009, to mark the occasion of its 50th anniversary, the College of Liberal Arts and Sciences, Northern Illinois University, recognized me for my accomplishments as one of its 50 most distinguished alumni. In 2012, I was awarded the American Chemical Society’s E. Emmett Reid Award, which recognizes high-quality teaching in chemistry at small colleges in the Mid-Atlantic region. In 2016 I earned two mentoring awards; the NIH-NIGMS INBRE Sidney A. McNairy, Jr. Mentoring Award, and the Delaware BioScience Association, Educator of the Year-Higher Education Award. In 2018, I received the Ignitor Award from the Delaware BioScience Association.

Our continued success in the Wesley-mentored undergraduate research program in chemistry has been recognized with articles in the state’s flagship newspapers: The Delaware News Journal and The Delaware State News. Articles have also appeared in the Dover Post, Hockessin Community News, Milford Beacon, and Delaware Today.

In 2010, the Strategic Pharmaceutical Advisors (SRxA’s) Word on Health used our drug development informatics findings ( to corroborate the criticism of the Food and Drug Administration (FDA) from the Government Accountability Office (GAO).

In October 2012, the European International Innovations, a magazine devoted to disseminating science, research, and technology information, featured the decade-long transformation that the Wesley undergraduate research program has produced. The article outlined how the program has created a dynamic and exciting environment where research drives undergraduate teaching for student benefit (

In June 2013, the well-read NerdWallet blog used our mentored research program as an example when putting forward compelling suggestions as to how to achieve success in diversifying the STEM fields (

The initiatives for integrating project-based STEM learning into the College-core were featured in the May 2014 issue of International Innovations (

In September 2015, in order to advance the national conversation about diversity and inclusion, the oldest and largest higher education diversity magazine Insights into Diversity, published an article highlighting the efforts within our Cannon Scholar program (

In April 2016, I provided input to a detailed study about greenest US States (

In May 2016, I authored an article for the Delware News Journal, Projecting the Future: STEM Job Prospects Will Boom (

In November 2016, I was a panelist on the Delaware STEMCouncil’s STEM Symposium (‘not-told-complete-story-all-scientists’-leaders-talk-equality-stem).

In 2017, I was involved in an Obesity Case Study with fellow Wesley faculty and students.

To help build a STEM capable workforce with increased participation from women and underrepresented minorities, I established the Wesley College’s STEM program launched the STEM Undergraduate Research – Center for Analytics, Talent and Success (UR-CATS) (

Publications (past five years)


  1. “Data-intensive Undergraduate Research Project Informs to Advance Healthcare Analytics,” D’Souza, M. J.; Wentzien, D. E.; Bautista, R. C.; Santana, J. R.; Skivers, M.; Stotts, S.; Fiedler, F. In 2018 Signal Processing in Medicine and Biology (SPMB18), IEEE Xplore, 2018, In Press.
  2. “Classical tosylate/chloride leaving group approach supports a tetrahedral transition state for additions to trigonal carbon,” D’Souza, M. J.; Wirick, J.; Deol, J.; Kevill, D. N. Research Trends in Organic Chemistry, 2018, In Press.
  3. “Data Talks: Obesity-Related Influences on US Mortality Rates,” D’Souza, M. J.; Bautista, R. C.; Wentzien, D. E. Research Health Science, 2018, 3(3), 65-78, PMCID: PMC6070145.
  4. “Correlation of the Rates of Solvolysis of α-Bromoisobutyrophenone Using Both Simple and Extended Forms of the Grunwald-Winstein Equation and the Application of Correlation Analysis to Related Studies,” Kevill, D. N.; Kim, C. -B.; D’Souza, M. J. European Journal of Chemistry, 2018, 9(1), 1-6, PMCID: PMC5909717.
  5. “Working with the Wesley College Cannon Scholar Program: Improving Retention, Persistence, and Success,” D’Souza, M. J.; Shuman, K. E.; Wentzien, D. E.; Roeske, K. P. Journal STEM Education, 2018, 19(1), 31-40, PMCID: PMC6059652.


  1. “Free Inventory Platform Manages Chemical Risks, Addresses Chemical Accountability, And Measures Cost-Effectiveness,” D’Souza, M. J.; Roeske, K. P.; Neff, L. S. International Journal of Advances in Science, Engineering, and Technology, 2017, 5(3, Spl. Issue 1), 25-29, PMCID: PMC5731657.
  2. “Investigation of Obesity-Related Mortality Rates in Delaware,” D’Souza, M. J.; Wentzien, D. E.; Bautista, R. C.; Gross, C. E. American Journal of Health Sciences, 2017, 8(1), 19-32, PMCID: PMC5501276.
  3. “Correlation of the Rates of Solvolysis of 4-Bromopiperidine a Reaction following a Grob Fragmentation Pathway,” Kevill, D. N.; Ryu, Z. H.; D’Souza, M. J. European Journal of Chemistry, 2017, 8(2), 162-167, PMCID: PMC5515489.
  4. Descriptive and Inferential Statistics in Undergraduate Data Science Research Projects. In T. Hokimoto, Hokkaido Information University, (Ed.), Advances in Statistical Methodologies and Their Application to Real Problems (pp. 295-315). D’Souza, M. J., Brandenburg, E. A., Wentzien, D. E., Bautista, R. C., Nwogbaga, A. P., Miller, R. G., & Olsen, P. E. (April 2017). Japan: InTech. doi: 10.5772/65721


  • “Integrative Approach for a Transformative Freshman-Level STEM Curriculum,” D’Souza, M.J.; Curran, K.L.; Olsen, P.E.; Nwogbaga, A.P.; Stotts, S.  Journal College Teaching & Learning, 2016, 13 (2), 47-64. PMCID: PMC4824183
  • “Mechanistic Studies of the Solvolyses of Carbamoyl Chlorides and Related Reactions,” Review Chapter, D’Souza, M.J.; Kevill, D.N. International Journal of Molecular Science, 2016, 17 (111), 20 pages, doi:10.3390/ijms17010111. PMCID: PMC4730352


  • “Integrative Wesley College Biological Chemistry Program Includes the Use of Informatics Tools, GIS and SAS Software Applications,” D’Souza, M. J.; Kashmar, R. J.; Hurst, K.; Fiedler, F.; Gross, C. E.; Deol, J. K.; Wilson, A. Contemporary Issues in Education Research, 2015, 8 (3), 193-214. PMCID: PMC4505611
  • “Strategies and Initiatives that Revitalize Wesley College STEM Programs,” D’Souza, M. J.; Kroen, W. K.; Stephens, C. B.; Kashmar, R. J. The Journal of College Teaching and Learning, 2015, 12(3), 195-208. PMCID: PMC4501633
  • “Evolution of a Structure-Searchable Database into a Prototype for a High-Fidelity SmartPhone App for 62 Common Pesticides Used in Delaware,” D’Souza, M.J.; Barile, B.; Givens, A.F. International Conference on Industrial Instrumentation and Control (2015 ICIC), IEEE XPlore, 2015, 71-76. PMC4604753
  • “Effect of Gender and Lifestyle Behaviors on BMI Trends in a Sample of the First State’s Undergraduate Population,” D’Souza, M. J.; Walls, K-J. E.; Rojas, C.; Everett, L. M.; Wentzien, D. E. American Journal of Health Sciences, 2015, 6(1), 59-74. PMCID: PMC4459742
  • “Statistical Methods for the Investigation of Solvolysis Mechanisms Illustrated by the Chlorides of the Carbomethoxy Protecting Groups NVOC and FMOC,” D’Souza, M. J.; Deol, J. K.; Pavey, M. T.; Kevill, D. N. Journal of Analytical Methods in Chemistry, 2015, vol. 2015, Article ID 941638, 8 pages, doi:10.1155/2015/941638, PMID:4342068


  • Review Chapter. “Influence of Sulfur for Oxygen Substitution in the Solvolytic Reactions of Chloroformate Esters and Related Compounds,” D’Souza, M. J.; Kevill, D. N. International Journal of Molecular Sciences, 2014, 15, 18310-18332, PMID: 25310653
  • “LFER Studies Evaluating Solvent Effects on an ?-Chloro- and two 1 ?,?,?-Trichloro- Ethyl Chloroformate Esters,” D’Souza, M. J.; Sandosky, B.; Fernandez-Bueno, G. A., McAneny, M. J. Canadian Chemical Transactions, 2014, 2, 160-174, PMID: 24812595


  • “Manipulating In-House Designed Drug Databases for the Prediction of pH-Dependent Aqueous Drug Solubility,” D’Souza, M. J.; AlAbed, G. J.; Earley, M.; Roberts, N.; Gerges, F. J. American Journal of Health Sciences, 2013, 4, 137-150, PMID: 24478935
  •  Review Chapter. “Application of the Grunwald-Winstein Equations to Studies of Solvolytic Reactions of Chloroformate and Fluoroformate Esters,” D’Souza, M. J.; Kevill, D.N. Research Recent Developments in Organic Chemistry, 2013, 13, 1-38, Editor, S. G.. Pandalai. Publisher, Transworld Research Network, Trivandrum-695 023 Kerala, India, ISBN: 978-81-7895-600-8, PMC4215406
  • “Kinetic Studies that Evaluate the Solvolytic Mechanisms of Allyl and Vinyl Chloroformate Esters,” D’Souza, M. J.; Givens, A.F.; Lorchak, P.A.; Greenwood, A.E.; Gottschall, S.M.; Carter, S.E.; Kevill, D. N. International Journal of Molecular Sciences, 2013, 14, 7286-7301. PMID: 23549265


  • “Inter-institutional Partnerships Propel a Successful Collaborative Undergraduate Degree Program in Chemistry,” D’Souza, M. J.; Wang, Q. J. College Teaching and Learning, 2012, 9, 245-252, PMID: 24273464
  • “Correlation of the Rates of Solvolysis of tert-Butyl Chlorothioformate and Observations Concerning the Reaction Mechanism,” Kyong, J.B.; Lee, Y.; D’Souza, M.J.; Mahon, B.P.; Kevill, D.N. European Journal of Chemistry, 2012, 3, 267-272, PMC3607629
  • “Evaluation of Electronic Effects in the Solvolyses of p-Methylphenyl and p-Chlorophenyl Chlorothionoformate Esters,” D’Souza, M. J.; Hampton, O. N.; Sansbury, B. M. Journal of Chemistry, Vol. 2013, 2012, Article ID 248534, 9 pages, PMID: 24377055
  • “Nucleophilic Participation in the Solvolyses of (Arylthio)methyl Chlorides and Derivatives: Application of Simple and Extended Forms of the Grunwald-Winstein Equations,” Kevill, D. N.; Park, Y. H.; Park, B.-C.; D’Souza, M. J. Current Organic Chemistry, 2012, 16, 2012, 1502-1511, PMID: 22711999
  • “Use of Linear Free Energy Relationships (LFERs) to Elucidate the Mechanisms of Reaction of a ?-Methyl-?-alkynyl and an ortho-Substituted Aryl Chloroformate Ester”, D’Souza, M .J.; Knapp, J. A.; Fernandez-Bueno, G. A.; Kevill, D. N. International Journal of Molecular Sciences, 2012, 13, 665-682, PMC3269712


  • Ph.D., Organic Chemistry, Northern Illinois University
  • M.S., Organic Chemistry, Northern Illinois University
  • M.S., Inorganic Chemistry, University of Bombay
  • B.S., Chemistry, University of Bombay

Courses Taught

  • BI406 Research Methods
  • BI407 Experimental and Project Research
  • CH130 Chemistry for Allied Health
  • CH200 Organic Chemistry I
  • CH210 Organic Chemistry II
  • CH265/365 Directed Research
  • CH326 Biochemistry

Contact Information