Wesley College’s Professor of Chemistry and Associate Dean of Interdisciplinary/Collaborative Research, Dr. Malcolm D’Souza, collaborated on a project featured in the European Journal of Chemistry with Chemistry Professor Dr. Dennis Neil Kevill from Northern Illinois University and Don-Eui University Professor, Dr. Zoon Ha Ryu.
The project was entitled: “Correlation Analysis of the Rates of Solvolysis of 4-bromopiperidine: A Reaction Following a Grob Fragmentation Pathway.”
Fragmentation reactions typically occur under mild conditions and are synthetically useful for the construction of complex natural products and olefins. Olefins are compounds containing multiple carbon-carbon bonds.
To resolve the behavior of neighboring group participation in such fragmentations, the European Journal of Chemistry article published on June 30, outlines Dr. D’Souza’s, Dr. Kevill’s, and Dr. Ryu’s interpretations for a synchronous Grob process in non-acidic solvents.
The organizations supporting this project are as follows: IDeA Networks of Biomedical Research Excellence (INBRE), and Experimental Program to Stimulate Competitive Research (EPSCoR).